Diffusion Diagrams: Voronoi Cells and Centroids from Diffusion

We define Voronoi cells and centroids based on heat diffusion. These heat cells and heat centroids coincide with the common definitions in Euclidean spaces. On curved surfaces they compare favorably with definitions based on geodesics: they are smooth and can be computed in a stable way with a single linear solve. We analyze the numerics of this approach and can show that diffusion diagrams converge quadratically against the smooth case under mesh refinement, which is better than other common discretization of distance measures in curved spaces. By factorizing the system matrix in a preprocess, computing Voronoi diagrams or centroids amounts to just back‐substitution. We show how to localize this operation so that the complexity is linear in the size of the cells and not the underlying mesh. We provide several example applications that show how to benefit from this approach.     

Hemlock Woolly Adelgid and Elongate Hemlock Scale Induce Changes in Foliar and Twig Volatiles of Eastern Hemlock

Eastern hemlock (Tsuga canadensis) is in rapid decline because of infestation by the invasive hemlock woolly adelgid (Adelges tsugae; ‘HWA’) and, to a lesser extent, the invasive elongate hemlock scale (Fiorinia externa; ‘EHS’). For many conifers, induced oleoresin-based defenses play a central role in their response to herbivorous insects; however, it is unknown whether eastern hemlock mobilizes these inducible defenses. We conducted a study to determine if feeding by HWA or EHS induced changes in the volatile resin compounds of eastern hemlock. Young trees were experimentally infested for 3 years with HWA, EHS, or neither insect. Twig and needle resin volatiles were identified and quantified by gas chromatography/mass spectrometry. We observed a suite of changes in eastern hemlock’s volatile profile markedly different from the largely terpenoid-based defense response of similar conifers. Overall, both insects produced a similar effect: most twig volatiles decreased slightly, while most needle volatiles increased slightly. Only HWA feeding led to elevated levels of methyl salicylate, a signal for systemic acquired resistance in many plants, and benzyl alcohol, a strong antimicrobial and aphid deterrent. Green leaf volatiles, often induced in wounded plants, were increased by both insects, but more strongly by EHS. The array of phytochemical changes we observed may reflect manipulation of the tree’s biochemistry by HWA, or simply the absence of functional defenses against piercing-sucking insects due to the lack of evolutionary contact with these species. Our findings verify that HWA and EHS both induce changes in eastern hemlock’s resin chemistry, and represent the first important step toward understanding the effects of inducible chemical defenses on hemlock susceptibility to these exotic pests.     

System Level Hardware/Software Partitioning Based on Simulated Annealing and Tabu Search

This paper presents two heuristics for automatic hardware/software partitioning of system level specifications. Partitioning is performed at the granularity of blocks, loops, subprograms, and processes with the objective of performance optimization with a limited hardware and software cost. We define the metric values for partitioning and develop a cost function that guides partitioning towards the desired objective. We consider minimization of communication cost and improvement of the overall parallelism as essential criteria during partitioning. Two heuristics for hardware/software partitioning, formulated as a graph partitioning problem, are presented: one based on simulated annealing and the other on tabu search. Results of extensive experiments, including real-life examples, show the clear superiority of the tabu search based algorithm.     

设计信息提高SEM缺陷检测取样效率

基于设计的分级将来自设计数据的版图信息与检测到的每个缺陷的相对位置结合起来,利用这种方法可提高缺陷帕雷托质量。通过对系统缺陷和有害缺陷进行分级,可以改进SEM检测。     

使用Lloyd Relaxation的物体表面网格化

根据输入的物体表面点云生成与表面点云拓扑结构一致且几何形状接近的三角网格,在计算机图形学建模中具有很重要的作用,提出一种基于Lloyd relaxation的模型表面点云网格化方法.首先从输人点云中随机选取一些样本点,样本点的数目可以指定;然后运用扩展的Lloyd relaxation算法将这些样本点沿着物体表面移动;当得到一个近似均匀的样本点分布后,运用改进的crust算法根据这些样本点生成三角网格.通过在每次relaxation过程中减少网格和曲面间体积的方法,使生成的三角网格与原始表面点云的几何形状接近.实验结果证明,该方法能正确、有效地生成输入点云模型的三角网格,并可以运用在三维物体表面重建和网格简化上.     

Imaging of Small Animal Peripheral Artery Disease Models: Recent Advancements and Translational Potential

Peripheral artery disease (PAD) is a broad disorder encompassing multiple forms of arterial disease outside of the heart. As such, PAD development is a multifactorial process with a variety of manifestations. For example, aneurysms are pathological expansions of an artery that can lead to rupture, while ischemic atherosclerosis reduces blood flow, increasing the risk of claudication, poor wound healing, limb amputation, and stroke. Current PAD treatment is often ineffective or associated with serious risks, largely because these disorders are commonly undiagnosed or misdiagnosed. Active areas of research are focused on detecting and characterizing deleterious arterial changes at early stages using non-invasive imaging strategies, such as ultrasound, as well as emerging technologies like photoacoustic imaging. Earlier disease detection and characterization could improve interventional strategies, leading to better prognosis in PAD patients. While rodents are being used to investigate PAD pathophysiology, imaging of these animal models has been underutilized. This review focuses on structural and molecular information and disease progression revealed by recent imaging efforts of aortic, cerebral, and peripheral vascular disease models in mice, rats, and rabbits. Effective translation to humans involves better understanding of underlying PAD pathophysiology to develop novel therapeutics and apply non-invasive imaging techniques in the clinic.     

Neuronal correlates of sensorimotor association in stimulus–response compatibility.

Neuronal mechanisms underlying stimulus–response (S-R) associations in S-R compatibility tasks were identified in 2 experiments with monkeys. Visual stimuli were presented on the left and right calling for left–right movements under congruent and incongruent S-R mapping instructions. High- and low-pitched tones calling for left–right movements were presented to the left and right ear, and the stimulus side was irrelevant. Single neurons sensitive to the S-R mapping rule were found in the primary motor cortex. The large overlap between the neuronal populations sensitive to the stimulus side, the S-R mapping rule, and the response side, respectively, is consistent with the idea that sensory-to-motor transformation is a continuous rather than a discrete process. Results partly support the hypothesis that the increase in reaction time with incongruent mapping is caused by the automatic activation of the congruent, but erroneous, response. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Pesticide measurements from the first national environmental health survey of child care centers using a multi-residue GC/MS analysis method

The U.S. Department of Housing and Urban Development, in collaboration with the U.S. Consumer Product Safety Commission and the U.S. Environmental Protection Agency, characterized the environments of young children (<6 years) by measuring lead, allergens, and pesticides in a randomly selected nationally representative sample of licensed institutional child care centers. Multi-stage sampling with clustering was used to select 168 child care centers in 30 primary sampling units in the United States. Centers were recruited into the study by telephone interviewers. Samples for pesticides, lead, and allergens were collected at multiple locations in each center by field technicians. Field sampling was conducted from July through October 2001. Wipe samples from indoor surfaces (floors, tabletops, desks) and soil samples were collected at the centers and analyzed using a multi-residue GC/MS analysis method. Based on the questionnaire responses, pyrethroids were the most commonly used pesticides among centers applying pesticides. Among the 63% of centers reporting pesticide applications, the number of pesticides used in each center ranged from 1 to 10 and the frequency of use ranged from 1 to 107 times annually. Numerous organophosphate and pyrethroid pesticides were detected in the indoor floor wipe samples. Chlorpyrifos (0.004-28 ng/cm2), diazinon (0.002-18 ng/cm2), cis-permethrin (0.004-3 ng/cm2), and